Triple X superwomen: their post-compulsory education and employability
Received 02 Feb 2020, Accepted 11 Dec 2020, Published online: 25 Jan 2021

‘You don’t know how big this heart is’: parental accounts of Triple X super-daughters’ life course and emerging community citizenship
Received 21 Aug 2022, Accepted 13 Feb 2023, Published online: 25 Feb 2023

"Triple X syndrome: Psychiatric disorders and impaired social functioning as a risk factor"
Published online by Cambridge University Press: 21 December 2022
Maarten Otter, Bea C. M. Campforts, Constance T. R. M. Stumpel, Thérèse A. M. J. van Amelsvoort en Marjan Drukker

Click on this link to read the article

AXYS Newsletter with the article
"The comorbidity landscape of 47,XXX syndrome: A nationwide epidemiologic study"
Agnethe Berglund, Kirstine Stochholm, Claus Gravholt. Genetics in Medicine 2022.

"Emotional reactivity and expressivity in young children with sex chromosome trisomies: evidence from psychophysiological and observational data"
Kimberly C. Kuiper ORCID Icon,Hanna Swaab,Nicole Tartaglia,Lisa Cordeiro &Sophie van Rijn
Received 13 Apr 2022, Accepted 11 Jul 2022, Published online: 25 Jul 2022

Second article related to the Dutch studie 2015-2018 Adults with Triple X Syndrome.
Maarten Otter, Bea C. M. Campforts, Constance T. R. M. Stumpel, Thérèse A. M. J. van Amelsvoort, Claudia Vingerhoets en Marjan Drukker.
This prelink (june 9, 2022) is available:

"Neuropsychological Findings in Adults with Triple X Syndrome"

New article by N Bouw, H Swaab, N Tartaglia, S van Rijn.
Published June 9, 2021
Archives of Clinical Neuropsychology
The Impact of Sex Chromosome Trisomies (XXX, XXY, XYY) on Early Social Cognition: Social Orienting, Joint Attention, and Theory of Mind

Article Feb 2021; Results Dutch studie Adults with Triple-X Syndrome 2015-2018
Maarten Otter, Peter M. L. Crins, Bea C. M. Campforts, Constance T. R. M. Stumpel,Thérèse A. M. J. van Amelsvoort and Claudia Vingerhoets

18 May 2020
Evaluating the Scope of Language Impairments in a Patient with Triple X Syndrome: A Brief Report

Urbanus E, Swaab H, Tartaglia N,Cordeiro L, S van Rijn:
The behavioral profile of children aged 1–5 years with sexchromosome trisomy (47,XXX, 47,XXY, 47,XYY)

Article Nov 2018; German resource
Behavioral and psychological features in girls and women with triple-X syndrome.

"Children with sex chromosome trisomies:
parental disclosure of genetic status".

"Increased prevalence of sex chromosome aneuploidies in specific language impairment and dyslexia"

Developmental Medicine & Child Neurology
Accepted for publication 9th August 2013.
Published online

"A tale worth telling: the impact of the diagnosis experience on disclosure of genetic disorders"

Journal of Intellectual Disability Research
Volume 59 part 5 pp 474–486 may 2015

Dr. Sophie van Rijn of Leiden University (The Netherlands) wins the Gratama Science Award 2013 for her study of the extra x effects on social development.

The article as a result of her study:
"The Social Behavioral Phenotype in Boys and Girls with an Extra X Chromosome (Klinefelter Syndrome and Trisomy X):
A Comparison with Autism Spectrum Disorder"

Sophie van Rijn • Lex Stockmann • Martine Borghgraef • Hilgo Bruining • Conny van Ravenswaaij-Arts • Lutgarde Govaerts • Kerstin Hansson •
Hanna Swaab

Springer Science+Business Media New York 2013

Poor socio-economic status in 47,XXX - an unexpected effect of an extra X
Kirstine Stochholm, Svend Juul, Claus H. Gravholt
European Journal of Medical Genetics (20 March 2013)

"Attention-Deficit Hyperactivity Disorder Symptoms in Children and Adolescents with Sex Chromosome Aneuploidy: XXY, XXX, XYY, and XXYY"
Nicole R. Tartaglia, MD,* Natalie Ayari, BA,* Christa Hutaff-Lee, PhD,* and Richard Boada, PhD
J Dev Behav Pediatr. 2012 May 9.

The Dutch psychiatrist Maarten Otter wrote his second article regarding Triple X Syndrome.
Before you read the article it's important to read his introduction.

Article USA published!
A review of trisomy X (47,XXX)
Orphanet Journal of Rare Diseases 11 May 2010
Nicole R. Tartaglia, Susan Howell, Ashley Sutherland, Rebecca Wilson, Lennie Wilson.

Corresponding author:

''Autism, language and communication in children with sex chromosome trisomies'''
Published July 23, 2010

Written by:
Dorothy V M Bishop, Patricia A Jacobs, Katherine Lachlan, et al.

New Italian article published
May 5, 2010 Milaan

''Triple X syndrome: characteristics of 42 Italian girls and parental emotional response to prenatal diagnosis''

Written by:
Soyhan Bağci, Andreas Müller, Axel Franz, Andreas Heydweiller,
Christoph Berg, Markus M. Nöthen, Peter Bartmann and Heiko Reutter.

"Neurocognitive outcomes of individuals with a sex chromosome
trisomy: XXX, XYY, or XXY: a systematic review"
Jan 5, 2010

July 2009
Article written by Drs Maarten Otter, psychiatrist in the Netherlands.

"Prenatal diagnosis and prognosis of triple X syndrome: 47, XXX"
Article written by Ben Hamouda H, et al, J Gynecol Obstet Biol Reprod (Paris) (2009), doi:10.1016/j.jgyn.2009.08.003
Service de pédiatrie,
Hôpital Universitaire Tahar Sfar
5111 Mahdia- Tunisie.

Child Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA. 2009.
Effects of sex chromosome aneuploidies on brain development: evidence from neuroimaging studies

Short description of the Triple X syndrome by the
”University of Michigan Medical Health System”.

Website of Genetics Home Reference; Your guide to understanding genetic Conditions"

Article about the origin of 47, XXY en 47, XXX aneuploidy;

“Margins of sexuality": the developmental differences associated with abnormal sexchromosomes are not always as devastating as once thought - includes related article”.

Article; "Gross and fine motor development in 45,X and 47,XXX girls"

Article; “No evidence of increased risk for schizophrenia or bipolar affective disorder in persons with aneuploidies of the sex chromosomes”.

Article; "Long term outcome in children of sex chromosome abnormalities "

Article; "Reduced size of the Amygdala in individuals with the 47,XXY en 47,XXX karyotypes”.

Article; "Neuropsychological and functional cognitive skills of 35 unselected adults with sex chromosome abnormalities"

Birth Defects Risk Factor Series by the
Texas Department of State Health Services with section on Triple X

Article; “Genetic Counseling for Sex Chromosome Abnormalities”

Article; "Intrauterine diagnosis of sex chromosome aneuploidy"

Article; "Sex Chromosome Abnormalities"

Article; "The growth of XXX females: population-based studies"

Canadian article 1983"The Triple X Chromosome Syndrome in Childhood: Recent Empirical Findings"

Article 2010 "Root length in the permanent teeth of women with an additional X chromosome (47,XXX females)".

Article 1987 "47,XXX females, sex chromosomes, and tooth crown structure"

UK Parents Not Given Enough Information About Fetal Genetic Disorders

[English section] [LINKS and ARTICLES]